Avanços no tratamento do queratocisto odontogênico comparando o uso das soluções de 5-fluorouracil e carnoy modificada: revisão de literatura

Abstract

The odontogenic keratocyst (OKC) is a benign lesion; however, it exhibits locally invasive and potentially destructive behavior, often associated with high recurrence rates. Therapeutic approaches include enucleation and curettage (EC), combined with peripheral ostectomy, followed by the application of chemical or topical chemotherapeutic agents, the most commonly used being the original Carnoy’s solution (CS), modified Carnoy’s solution (MCS), and 5-fluorouracil (5-FU). This study aims to conduct a literature review on adjuvant treatments for OKC using 5-FU and MCS, comparing their effectiveness regarding recurrence rates and paresthesia. The research was conducted in the PubMed, Science Direct, and CAPES Journal Portal databases, including articles published between 1994 and 2025 in Portuguese and English. Adjuvant therapies with MCS and 5-FU show promising results; however, further studies are needed to validate the long-term outcomes of 5-FU.