A correlação de microrganismos periodontais e a doença de Alzheimer: uma revisão de literatura

Abstract

The article highlights that Alzheimer's Disease (AD) may have a multifactorial origin, involving genetic, environmental, and inflammatory factors, and points to a possible relationship between periodontal microorganisms and the progression of the disease through neuroinflammation and neurodegeneration processes. It directly relates periodontal microorganisms, which cause periodontal disease (PD), as possible agents associated with AD, briefly explaining the pathogenic mechanisms of both diseases and their hypothesized role in neuroinflammation and neurodegeneration. The results pointed to a possible association between PD and AD, but causality was not established due to the small sample sizes of the studies reviewed. It was concluded that further studies are needed to effectively determine the correlation.